Genomics, Personalized Medicine, and Pediatrics

Pharmacogenetics/genomics and personalized medicine.

Despite the marked advances in drug therapy, some patients do not respond favorably or suffer severe adverse drug effects. Pharmacogenetic studies have shown that polymorphisms of drug metabolizing enzymes, transporters and receptors contribute to variable drug response. Owing to the complexity of drug actions, a broader genomics approach aims at finding new drug targets and optimizing therapy ...

personalized cancer medicine: a future direction of personal genomics

personalized medicine is significantly changing the fundamentals of healthcare. genetic diagnostic tests are used in various parts of medicine – from initial screening to the diagnosis and finally treatment. investigations in fields of drug development indicate that oncology may lead other therapeutic areas in the number of targeted therapies on the marketplace as well as in the pipeline, expec...

Genomics and the Reimagining of Personalized Medicine.

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Medicine. Racing forward: the Genomics and Personalized Medicine Act.

Pharmacogenomics: Translating functional genomics to personalized medicine

The emergence of human genome project brings hope of personalized medicine as patients with identical clinical symptoms may respond differently to the same drug therapy. Genetic polymorphisms in drug-metabolizing enzymes, transporters, receptors and other drug targets have been linked to differences in the efficacy and toxicity of many drugs between two individuals. Pharmacogenomics is the stud...